Nadia Luheshi

Nadia Luheshi

Company: AstraZeneca

Job title: Global Product Leader

Seminars:

MEDI1191, a Novel IL-12 mRNA Therapy for Intratumoral Injection 9:30 am

• Understand how IL-12 is a key driver of TH1 responses and anti-tumor immunity, but systemic recombinant IL-12 was poorly tolerated in early clinical trials • In preclinical models, intratumoral IL-12 mRNA drives IFNγ and CD8+ T cell-dependent anti-tumor immunity that is further enhanced by PD-L1 blockade • IT MEDI1191 is currently being evaluated in…Read more

day: Day Two

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